Influence of acute and prolonged inhibition of angiotensin converting enzyme (ACE) with cilazapril on regional hemodynamics in SHR

Attenuation of Focal Cerebral Ischemic Injury Following Post-Ischemic Inhibition of Angiotensin Converting Enzyme (ACE) Activity in Normotensive Rat

Background: Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (I/R) injuries. This study evaluated the impacts of post-ischemic inhibition of ACE, enalapril, on brain inf...

Study of Serum and Tissues Angiotensin Converting Enzyme (ACE) Activity in Rat with Gentamicin Induced Renal Toxicity

The angiotensin I-converting enzyme (ACE) converts the inactive angiotensin I molecule to the active angiotensin II. ACE is rich in epithelium, endothelium, and neuroepithelial cells and it found largely on the brush border of intestine and kidney proximal tubules. ACE also presents in the serum. Some pulmonary and renal toxic drugs change the serum and tissue ACE contents. In this research ACE...

Inhibition of Angiotensin Converting Enzyme (ace) by Viola Mandshurica Extraction

Angiotensin-converting enzyme (ACE, EC 3.4.15.1) inhibitor plays a critical role in treating hypertension by causing blood vessels to constrict. The purpose of this study was to estimate ACE inhibition activity by Viola mandshurica using an in vitro assay. The assay method is based on the hydrolysis of the substrate HHL by ACE, and measuring the amount of HA using RP-HPLC. ACE inhibitor activit...

Angiotensin Converting Enzyme in Sarcoidosis

Effects of long-term blockade of angiotensin converting enzyme with captopril (SQ14,225) on hemodynamics and circulating blood volume in SHR.

Male spontaneously hypertensive rats (SHR), 13 weeks old, received oral administration of captopril (SQ14,225) daily at a dose of 10 mg/kg or 30 mg/kg; or water at 2 ml/kg, for 6 weeks. Captopril suppressed the development of hypertension slightly at the lower dose and completely at the higher dose. At 6 weeks of dosing, hemodynamic parameters were measured by the tracer microsphere method and ...